Cancer is a life-threatening condition that is characterized by uncontrolled growth and spread of tumour cells. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Tumor growth and metastases are dependent on angiogenesis, the growth of new blood vessels from pre-existing blood vessels. The process involves the development and release of angiogenic growth factors such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor-2 (FGF-2) and Transforming Growth Factor-β (TGFβ) which bind to endothelial cell receptors. Tumor growth occurs exponentially as a result of endothelial cell migration and proliferation brought on by endothelial receptor binding and activation. Therefore, angiogenesis is a critical phase in tumour development, invasion, and metastases.
Author(s) Details:
Jyothi Bandi,
Department of Chemistry, University College of Science, Osmania University, Hyderabad – 500007, Telangana State, India.
Navaneetha Nambigari,
Department of Chemistry, University College of Science, Osmania University, Hyderabad – 500007, Telangana State, India and Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad – 500004, Telangana State, India.
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