Histologic grade is a significant predictor of outcome in salivary gland carcinomas. However, the sheer variety of tumor type and the rarity of these tumors pose challenges to devising highly predictive grading schemes. As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested. Oral squamous cell carcinoma (OSCC) has a relatively unfavorable prognosis with a 35 to 50% of 5-year survival. For many years, TNM staging system has been used to clinically estimate response to therapy and survival, but this staging system is not sufficient for optimal prognostication and must be supplemented by other reliable methods. Management of OSCC is based on surgical resection with or without adjuvant treatment (e.g. radiotherapy or chemoradiotherapy). The indication for adjuvant treatment is influenced by features detailed in the standardized histopathology report of the resection, which include differentiation, growth pattern, depth of invasion, status of margins, vascular/neural invasion, bone involvement, nodal status. The patients who die of OSCC, despite the fact that their neoplasms were considered clinically to be stages I and II, a combined assessment of clinical staging and cytomorphology of the neoplasms might serve as a more precise measure for predicting the outcome of the neoplasm and for determining their treatment in such patients.
Author(s) Details:
Varun Rastogi,
Department of Oral Pathology, UCMS, Bhairahawa, Nepal.
Nisha Maddheshiya,
Department of Oral Medicine & Radiology, IMS, Faculty of Dental Sciences, BHU, Varanasi, India.
Nitin Sangwan,
Department of Periodontology, UCMS, Bhairahawa, Nepal.
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