Since its discovery in 1895, ionizing radiation has been essential in medical settings for diagnostics and radiotherapy. Its importance comes from its ability to be used for non-invasive visualization of internal structures and for advanced diagnostics.
In 1920s and 1930s, RWs routinely had their blood tested once a week in the hematologic laboratory. This was the only type of monitoring available before personal radiation detectors were developed.
After years of dealing with radiation, its effects are now divided into two types: the deterministic effect caused by high radiation doses, ranging from death to skin effects, which are not common in diagnostic radiology. The second effect is the stochastic effect induced by low radiation doses over a long time, involving radiation-induced cancer and genetic alterations. Low radiation doses given over an extended period are more common among occupational RWs.
Author(s) Details:
Areej Dahdol
Palestinian Ministry of Health, Salfit, Palestine and Department of Medical Imaging, Faculty of Health Professions, Al-Quds University, Jerusalem, Palestine.
Mohammad Hjouj
Department of Medical Imaging, Faculty of Health Professions, Al-Quds University, Jerusalem, Palestine.
Recent Global Research Developments in Tumor Biomarkers: Diagnosis, Prognosis, and Targeted Therapy
Editorial: New Progress in Cancer Biomarkers and Therapy:
- This editorial discusses the latest data on cancer biomarkers, emphasizing their clinical implications. These biomarkers aid in early detection, monitoring treatment progress, and predicting cancer prognosis [1].
Development of Novel Cancer Biomarkers:
- Rapid progress in diagnostic and prognostic biomarkers has led to companion diagnostics and targeted therapies for cancer patients. These advancements improve diagnosis and reduce unnecessary chemotherapy and associated toxicities [2].
Blood Biomarkers in Neuro-oncology:
- A comprehensive review highlights recent advances in blood biomarker development for adult and pediatric brain tumors. These biomarkers play a crucial role in early intervention and personalized therapy decisions [3].
Tumor Biomarkers for Diagnosis, Prognosis, and Targeted Therapy:
- Recent breakthroughs in biomarker-based anticancer therapies are promising. E-cadherin, for example, is closely linked to tumor characteristics and prognosis [4].
Glycoproteomic Analysis for Biomarker Discovery:
- Glycoproteomic analysis shows promise in early cancer detection and predicting treatment efficacy, including response to immunotherapies [5].
References
- Editorial: New progress in cancer biomarkers and therapy
https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1388872/pdf - Janjua, K.A., Shahzad, R., Shehzad, A. (2022). Development of Novel Cancer Biomarkers for Diagnosis and Prognosis. In: Shehzad, A. (eds) Cancer Biomarkers in Diagnosis and Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-16-5759-7_11
- Foster, J.B., Koptyra, M.P. & Bagley, S.J. Recent Developments in Blood Biomarkers in Neuro-oncology. Curr Neurol Neurosci Rep 23, 857–867 (2023). https://doi.org/10.1007/s11910-023-01321-y
- Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., … & Zhao, Y. (2024). Tumor biomarkers for diagnosis, prognosis and targeted therapy. Signal Transduction and Targeted Therapy, 9(1), 132.
- He, K., Baniasad, M., Kwon, H. et al. Decoding the glycoproteome: a new frontier for biomarker discovery in cancer. J Hematol Oncol 17, 12 (2024). https://doi.org/10.1186/s13045-024-01532-x
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